|Matrixyl, otherwise known as Palmitoyl pentapeptide-3 or Palmitoyl pentapeptide-4 is a peptide increasingly being used in skin care formulations. Matrixyl is included in skin care treatments for its ability to reduce the appearance of wrinkles as effectively as retinol, but without the skin irritation associated with retinol’s use.
Matrixyl was developed by Sederma SA. It is made up of five amino acids that are linked together and attached to a fatty acid. The fatty acid component of the molecule increases Matrixyl’s absorption into the skin. Matrixyl is structurally related to the precursor of collagen type I (procollagen type I) and studies have shown that it stimulates the synthesis of the key constituents of the skin matrix: collagen, elastin and glycosaminoglycans.
How does Matrixyl Work?
It’s not exactly clear how Matrixyl works, but a number of theories exist. According to Sederma, Matrixyl stimulates fibroblasts (cells that synthesize and maintain the extracellular matrix of tissues providing a structural framework for skin) to synthesize collagen I, collagen IV, fibronectin and glycosaminoglycans, restoring the matrix and epidermal-dermal junction to reduce wrinkles.
Studies have shown that Matrixyl can:
- Decrease skin roughness by 13%
- Reduce wrinkle volume by 36%
- Decrease wrinkle depth by 27% after four months of twice-daily applications on the face and neck
- Increase skin thickness.
Matrixyl’s anti wrinkle benefits are supported by two studies conducted by Sederma. In the first study, 16 volunteers applied a cream with 3 percent Matrixyl or a cream with 0.07 percent retinol. Study subjects applied the cream daily for two months and then twice daily for two months. Both treatments showed similar results in reducing wrinkle depth, wrinkle surface and wrinkle length. Skin thickness increased by 6.5 percent after two months and 8.6 percent after four months with Matrixyl; retinol increased skin thickness by 4.0 percent after two months and 8.7 percent after four months.
In the second study, two groups of 30 volunteers, used a 5 percent Matrixyl cream or a placebo cream twice daily on face and décolleté for four months. A 13-percent net decrease in roughness was obtained with Matrixyl after four months, compared to no change with placebo. In addition, after four months, Matrixyl had a 27-percent improvement in wrinkle mean depth and 36-percent improvement in wrinkle volume.
Matrixyl is well tolerated and no side effects have been reported.
If you cannot tolerate retinoids or alpha hydroxy acids, then Matrixyl might be the right choice for you. Additionally, since Matrixyl is well tolerated and no side effects have been reported, it can easily be incorporated into your existing anti aging skin care regimen. Here are some products to consider:
|This triple-action concentrate of non-irritating emolient ingredients and botanicals work together to produce both and immediate moisturizing effect as well as long-term benefits. Clinical testing shows a 68% reduction of deep surface wrinkles over a two-month period.|
|5% Matrixyl plus a blend of proprietary anti aging ingredients will help to reduce wrinkle width, length and number.|
|Matrixyl, glycolic acid, Vitamin E, provitamin B and glycerin are included in this hydrating and rejuvenating formulation will reduce the appearance of fine lines and wrinkles.|